Bio-Immunozyme Forte™ provides A unique, broad-spectrum multiple designed to specifically support normal, healthy immune function. It also provides a wide array of vitamin, mineral, botanical, amino acid and organ/glandular specific support. For more information about Bio-Immunozyme Forte™ , please click the file below:
Key Ingredients and the role they play on your Immune System:
Important Vitamins
Vitamin A: has long been known to support mucosal cell surfaces and the immune system.(1) Vitamin A helps maintain the integrity of lymphatic tissues, antibody levels (especially sIgA), and responses of cellular immunity to challenge by exogenous stimulatory substances.
Vitamin C: scavenges free radicals and is essential for the function of many systems, including the immune system. Vitamin C is required for eicosanoids that regulate inflammation and it combats the effects of oxidative stress. Vitamin C is a major antioxidant in the blood and it works together with vitamin E.
Vitamin B6: have specifically shown an ability to enhance antibody production. It is required by transaminases and amino acid decarboxylases in the breakdown of amino acids. As such, vitamin B6 plays a critical role in all rapidly dividing cell types. Ultimately, it helps create cells needed to beat viruses.
Important Minerals
Selenium: is a trace mineral that is converted to selenocysteine, which plays a catalytic role in glutathione peroxidase production. In this sense, selenium can be considered an antioxidant. Selenium has a major impact on the immune system. Selenium deficiency can lead to depressed immunity and reduced T-cells.
Copper, Manganese and Zinc: Manganese SOD and copper-zinc SOD activities in lymphocytes and neutrophils were not inducible by cytokines in elderly subjects, although these activities were readily inducible in nonaged subjects.(22) These results suggested an age related alteration in the regulation of these defensive enzymes.
Zinc plays an important role in maintaining the health of the immune system. It is a required cofactor for DNA polymerase and RNA polymerase, essential for cell proliferation. Rapidly dividing cells, including mucosal cells and immune cells, require zinc. Zinc deficiency leads to atrophy of lymphatic tissues, decreased skin delayed hypersensitivity response, impaired phagocytes, decreased T-cell function and lowered IgA and decreased thymic hormone activity.(25,26) Zinc supports granulocyte chemotaxis in vitro. (27)
The Other "Stuff"
Bio-Immunozyme Forte™ contains bovine neonatal thymus, spleen, liver, pancreas, in addition to bovine parotid gland, lymphatic and placental tissues. These glandular preparations are processed to maintain nutrients, enzymes and associated factors.
Co-Factors: Carotenoids complement vitamin E as lipid-soluble antioxidants. The natural mixed carotenoids are better absorbed and are more effective antioxidants than synthetic beta carotene in vivo. (12) By acting as antioxidants, carotenoids can limit lipid peroxidation.(13) As example, beta carotene supplementation reduced lipid peroxidation in smokers(14) beta carotene has long been known to have a protective impact on the immune Bio-Immunozyme Forte™ system.
Co-Q10: functions both as an essential mitochondrial electron carrier for energy production and as a lipid-soluble antioxidant. Coenzyme-Q10 together with vitamin B6 supported the production of T4-lymphocytes and immunoglobulins. (20)
References:
1. Bates C.J. Vitamin A. Lancet 1995; 345: 31-34
2. Ongsakul M et al. Impaired blood clearance of bacteria and phagocytic activity in vitamin A deficient rats. Proc Soc Exp Biol Med. 1985; 178: 204 408.
3. de Pee S et al. Lack of improvement in vitamin A status with increased consumption of dark green leafy vegetables Lancet. 1995; 346: 75-81.
4. Ginter E. Optimum intake of vitamin C for the human organism.Nutr health 1982; 1: 66-77.
5. Herbaczynska-Cedro K et al. supplementation with vitamin C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction. Eur Heart J. 1995; 16: 1044-1049.
6. Vojdani A and Ghoneum M. In vivo effect of ascorbic acid
7. AM. J. Clin. Nutri.: 35: 417-468, 1982.
8. Rall LC, Meydani SN. Vitamin B6 and immune competence.Nutri Rev. 1992; 50: 145-147.
9. Casciato DA et al. Immunologic abnormalities in hemodialysis patients: improvement after pyridoxine therapy. Nephron 1984: 38: 9-16.
10. Nutri. Anti-Infectious Defense: p. 130, 1974.
11. Vitamins & Hormones: 11:133, 1953.
12. Ben-Amotz A and Levy Y. Bioavailability of anatural isomer mixture compared with synthetic, all trans beta carotene in human serum. Am J Clin Nutri 1996; 63: 729-734.
13. Levin G and Mokady S. Antioxidant activity of 9-cis compared to all-trans beta carotene. Free Radic Biol Med 1994; 17: 77-82.
14. Allard JP et al. Effects of beta carotene supplementation in lipid peroxidation in humans. Am J Clin Nutr. 1994; 9:884-890.
15. Murata J et al. Effect of long term administration of beta carotene on lymphocyte subsets in humans. Am J. Clin Nutr. 1994; 60:597-602.
16. Huges DA et al. The effect of beta carotene supplementation on the immune function of blood monocytes from healthy nonsmokers. J Lab Clin Med. 1997: 129: 309-317.
17. Stocker R et al. Ubiquinol-10 protects human low density lipoproteins more efficiently against lipid peroxidation than does a tocopherol. Proc Natl Acad Sci 1991; 88: 1646-1650.
18. Weber C et al. Antioxidative effect of dietary coenzyme-Q10 in human blood plasma. Int J Vit Nutri Res 1994; 64: 311-315.
19. Bliznakov EG et al. Coenzyme-Q deficiency in aged mice. J Medicine 1978; 9: 337-396. 20. Folkers E et al. The activities of coenzyme-Q10 and vitamin B6 inimmune responses. Biochem Biophy Res Commun. 1993; 193: 88-92.
21. Taylor EW. Selenium and cellular immunity. Evidence that selenoproteins ;may be encoded in the +1 reaching from overlapping the human CD4, CD8, HLA-DR genes. Biol. Trace Elem Res 1995; 49: 85- 95.
22. Niwa Y et al. Age-dependent basal level and induction capacity of copper-zinc and manganese superoxide dismutase and other scavenging enzyme activities in leukocytes for young and elderly adults. Am J Pathol 1993; 143: 312-320.
23. Milne DB. Assessment of copper nutritional status. Clin Chem 1994; 40: 1479-1484.
24. ntrona M, Moss J, Ronzio RA. The effect of oral supplementation with legume derived superoxide dismutase on erythrocyte superoxide dismutase in healthy volunteers. Appl Nutr, 1997; 49 (1,2): 12-17.
25. Castillo-Duran C et al. Controlled trial of zinc supplementation during recovery for malnutrition. Am J Clin Nutr 1987; 45: 602-608.
26. Chandra RK. Symposium on nutrition and immunity in serious illness. Proc Nutr Soc 1993; 52: 77-84.
27. Ventura MT et al. In vitro correction of defective granulocytes chemotaxis in the elderly. IRCS Med Soc 1985; 13: 535-536.
28. Genova R, Guerra A. Thymo-modulin in management of food allergy in children. In J Tiss Reac 1986; 8: 239-242.
29. Obminska-Domoradzka B, Debowy J. Effect of DTC in humoral response of SRBCImmunized mice exposed to restraint stress. Comparison with calf thymus extract. Immuno pharmacol Immunotoxicol 1996; 18: 421-431.
30. Krasowski H et al. Einfluss von Kalbermilz- und Kalber Thymus Extrackten hymopentiund T00uftsin auf du Phagozytosiaktivitat von neutrophilen Giranulozyten. Arzneimiltelforshung 1992; 42: 147-151.
31. Sabbadini E, Bercz I. The submandibular gland: a key organ in the neuro immuno - regulatory network? Neuroimmunomodulation 1995; 2: 184-202.
32. Fernandes CF and Shahani KM. Modulation of antibiosis by lactobacilli and other lactic cultures and fermented foods.
33. Fernandes CF et al. Control of diarrhea by lactobacilli. J Applied Nutri 11988; 40: 32-43.
34. Metabolicmanagement.com
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